MAGNOLOL ENHANCES THE THERAPEUTIC EFFECTS OF TRAIL THROUGH DR5 UPREGULATION AND DOWNREGULATION OF C-FLIP AND MCL-1 PROTEINS IN CANCER CELLS

Magnolol Enhances the Therapeutic Effects of TRAIL through DR5 Upregulation and Downregulation of c-FLIP and Mcl-1 Proteins in Cancer Cells

Magnolol is a biologically active compound, isolated from the Chinese herb Magnolia, that regulates antiproliferative, anticancer, antiangiogenic and antimetastatic activities.We found that magnolol sensitizes TRAIL-induced apoptotic cell sten jacket m death via upregulation of DR5 and downregulation of cellular FLICE-inhibitory protein (c-FLIP) an

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